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N Engl J Med. Through a negative feedback loop, exogenous therapy suppresses gonadotropin secretion from the pituitary gland, leading to a reduction in androgen production Use of anti-androgenic therapy as an adjunct helps to achieve maximum change. There is no evidence that higher estradiol levels in patients with adequate androgen suppression results in additional feminization or breast development. Principles and Practice of Endocrinology and Metabolism. Expert Consult - Online. Estrogen receptor modulators.

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Once this has been achieved, titration efforts can focus on increasing androgen blockade.

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JZ Erkr Atmungsorgane. Spironolactone has been studied in fibromyalgia in women. Despite these metabolic changes, and negative impact on potential risk factors for cardiovascular disease, no studies have found an increase in the occurrence of cardiovascular events such as myocardial infarction, deep vein thrombosis, and cerebrovascular events 1629

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Spironolactone is marketed under a large number of brand names throughout the world.

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